Multiple Signals Regulate Nicotine Synthesis in Tobacco Plant

Clustered transcription factor genes regulate nicotine biosynthesis in tobacco.

Tobacco (Nicotiana tabacum) synthesizes nicotine and related pyridine alkaloids in the root, and their synthesis increases upon herbivory on the leaf via a jasmonate-mediated signaling cascade. Regulatory NIC loci that positively regulate nicotine biosynthesis have been genetically identified, and their mutant alleles have been used to breed low-nicotine tobacco varieties. Here, we report that ...

Multiple signals regulate GAL transcription in yeast.

Gal4p activates transcription of the Saccharomyces GAL genes in response to galactose and is phosphorylated during interaction with the RNA polymerase II (Pol II) holoenzyme. One phosphorylation at S699 is necessary for full GAL induction and is mediated by Srb10p/CDK8 of the RNA Pol II holoenzyme mediator subcomplex. Gal4p S699 phosphorylation is necessary for sensitive response to inducer, an...

Tobacco & Nicotine - nicotine as therapy

Nicotine & Tobacco Research

Nicotine & Tobacco Research Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t713439766 Lack of effect of D2 dopamine receptor TaqI A polymorphism on smoking cessation Ivan Berlin a; Lirio S. Covey b; Huiping Jiang c; Dean Hamer d a Département de Pharmacologie, Groupe Hospitalier Universitaire Pitié-Salpêtrière...

Determination of Nicotine Absorption from Multiple Tobacco Products and Nicotine Gum

INTRODUCTION Snus is a smokeless tobacco product traditionally used in Scandinavia and available in pouched or loose forms. The objective of this study was to determine nicotine absorption for current pouched and loose snus products in comparison with a cigarette and an over-the-counter nicotine gum. METHODS We conducted an open-label, randomized, 6-way, crossover study involving 20 healthy s...